Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors

[Image: see text] Indoleamine-2,3-dioxygenase-1 (IDO1) has emerged as an attractive target for cancer immunotherapy. An automated ligand identification system screen afforded the tetrahydroquinoline class of novel IDO1 inhibitors. Potency and pharmacokinetic (PK) were key issues with this class of c...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Li, Derun, Deng, Yongqi, Achab, Abdelghani, Bharathan, Indu, Hopkins, Brett Andrew, Yu, Wensheng, Zhang, Hongjun, Sanyal, Sulagna, Pu, Qinglin, Zhou, Hua, Liu, Kun, Lim, Jongwon, Fradera, Xavier, Lesburg, Charles A., Lammens, Alfred, Martinot, Theodore A., Cohen, Ryan D., Doty, Amy C., Ferguson, Heidi, Nickbarg, Elliott B., Cheng, Mangeng, Spacciapoli, Peter, Geda, Prasanthi, Song, Xuelei, Smotrov, Nadya, Abeywickrema, Pravien, Andrews, Christine, Chamberlin, Chad, Mabrouk, Omar, Curran, Patrick, Richards, Matthew, Saradjian, Peter, Miller, J. Richard, Knemeyer, Ian, Otte, Karin M., Vincent, Stella, Sciammetta, Nunzio, Pasternak, Alexander, Bennett, David Jonathan, Han, Yongxin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2021
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957919/
https://ncbi.nlm.nih.gov/pubmed/33738066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00525
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