Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2

Indoleamine 2,3-dioxygenases (IDOs) are tryptophan-catabolizing enzymes with immunomodulatory functions. However, the biological role of IDO2 and its relationship with IDO1 are unknown. To assess the relationship between IDO2 and IDO1, we investigated the effects of co-expression of human (h) IDO2 o...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Lee, Young-Kwan, Lee, Hoon Bok, Shin, Dong-Mi, Kang, Min Jueng, Yi, Eugene C, Noh, Seungjoo, Lee, Jaewoo, Lee, Chulbom, Min, Chang-Ki, Choi, Eun Young
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261913/
https://ncbi.nlm.nih.gov/pubmed/25394548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2014.69
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