The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells

1-methyl-D-tryptophan (1-D-MT) is currently being used in clinical trials in patients with relapsed or refractory solid tumors with the aim of inhibiting indoleamine-2,3-dioxygenase (IDO)-mediated tumor immune escape. IDO is expressed in tumors and tumor-draining lymph nodes and degrades tryptophan...

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Detalhes bibliográficos
Main Authors: Opitz, Christiane A., Litzenburger, Ulrike M., Opitz, Uta, Sahm, Felix, Ochs, Katharina, Lutz, Christian, Wick, Wolfgang, Platten, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098827/
https://ncbi.nlm.nih.gov/pubmed/21625531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019823
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