RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP)

Many biological processes are RNA-mediated, but higher-order structures for most RNAs are unknown, making it difficult to understand how RNA structure governs function. Here we describe SHAPE mutational profiling (SHAPE-MaP) that makes possible de novo and large-scale identification of RNA functiona...

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Bibliografiske detaljer
Udgivet i:Nat Methods
Main Authors: Siegfried, Nathan A., Busan, Steven, Rice, Greggory M., Nelson, Julie A.E., Weeks, Kevin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259394/
https://ncbi.nlm.nih.gov/pubmed/25028896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3029
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