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Angiotensin II Stimulates Protein Kinase D–Dependent Histone Deacetylase 5 Phosphorylation and Nuclear Export Leading to Vascular Smooth Muscle Cell Hypertrophy

BACKGROUND: Angiotensin II (Ang II) induces the phenotypic modulation and hypertrophy of vascular smooth muscle cells (VSMCs), which is implicated in the pathogenesis of hypertension, atherosclerosis, and diabetes. In this study, we tested the hypothesis that histone deacetylases 5 (HDAC5) and its s...

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Dettagli Bibliografici
Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Xu, Xiangbin, Ha, Chang-Hoon, Wong, Chelsea, Wang, Weiye, Hausser, Angelika, Pfizenmaier, Klaus, Olson, Eric N., McKinsey, Timothy A., Jin, Zheng-Gen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259271/
https://ncbi.nlm.nih.gov/pubmed/17823368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.107.151704
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