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Angiotensin II Stimulates Protein Kinase D–Dependent Histone Deacetylase 5 Phosphorylation and Nuclear Export Leading to Vascular Smooth Muscle Cell Hypertrophy

BACKGROUND: Angiotensin II (Ang II) induces the phenotypic modulation and hypertrophy of vascular smooth muscle cells (VSMCs), which is implicated in the pathogenesis of hypertension, atherosclerosis, and diabetes. In this study, we tested the hypothesis that histone deacetylases 5 (HDAC5) and its s...

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Опубликовано в: :Arterioscler Thromb Vasc Biol
Главные авторы: Xu, Xiangbin, Ha, Chang-Hoon, Wong, Chelsea, Wang, Weiye, Hausser, Angelika, Pfizenmaier, Klaus, Olson, Eric N., McKinsey, Timothy A., Jin, Zheng-Gen
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259271/
https://ncbi.nlm.nih.gov/pubmed/17823368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.107.151704
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