PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy

Dynamic nucleocytoplasmic shuttling of class IIa histone deacetylases (HDACs) is a fundamental mechanism regulating gene transcription. Recent studies have identified several protein kinases that phosphorylate HDAC5, leading to its exportation from the nucleus. However, the negative regulatory mecha...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ha, Chang Hoon, Kim, Ji Young, Zhao, Jinjing, Wang, Weiye, Jhun, Bong Sook, Wong, Chelsea, Jin, Zheng Gen
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932618/
https://ncbi.nlm.nih.gov/pubmed/20716686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000462107
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