Protein Kinase D-dependent Phosphorylation and Nuclear Export of Histone Deacetylase 5 Mediates Vascular Endothelial Growth Factor-induced Gene Expression and Angiogenesis

Vascular endothelial growth factor (VEGF) is essential for normal and pathological angiogenesis. However, the signaling pathways linked to gene regulation in VEGF-induced angiogenesis are not fully understood. Here we demonstrate a critical role of protein kinase D (PKD) and histone deacetylase 5 (H...

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Main Authors: Ha, Chang Hoon, Wang, Weiye, Jhun, Bong Sook, Wong, Chelsea, Hausser, Angelika, Pfizenmaier, Klaus, McKinsey, Timothy A., Olson, Eric N., Jin, Zheng-Gen
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386927/
https://ncbi.nlm.nih.gov/pubmed/18332134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800264200
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