Splenectomy Promotes Indirect Elimination of Intraocular Tumors by CD8(+) T cells That Is Associated with IFNγ and Fas/FasL-dependent Activation of Intratumoral Macrophages

Ocular immune privilege (IP) limits immune surveillance of intraocular tumors as certain immunogenic tumor cell lines (P815, E.G7-OVA) that are rejected when transplanted in the skin grow progressively when placed in the anterior chamber (a.c.) of the eye. As splenectomy (SPLNX) is known to terminat...

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Publié dans:Cancer Immunol Res
Auteurs principaux: Miller, Maxine R., Mandell, Jonathan B., Beatty, Kelly M., Harvey, Stephen A. K., Rizzo, Michael J., Previte, Dana M., Thorne, Stephen H., McKenna, Kyle C.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258428/
https://ncbi.nlm.nih.gov/pubmed/25248763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0093-T
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