The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability

Using fluorescent variants of Fas and FasL, we show that membrane FasL and Fas form supramolecular clusters that are of flexible shape, but nevertheless stable and persistent. Membrane FasL-induced Fas clusters were formed in caspase-8– or FADD-deficient cells or when a cytoplasmic deletion mutant o...

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Bibliographic Details
Main Authors: Henkler, Frank, Behrle, Eva, Dennehy, Kevin M., Wicovsky, Andreas, Peters, Nathalie, Warnke, Clemens, Pfizenmaier, Klaus, Wajant, Harald
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171833/
https://ncbi.nlm.nih.gov/pubmed/15795317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200501048
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