Involvement of IFN-γ and Perforin, but not Fas/FasL interactions in regulatory T cell-mediated suppression of experimental autoimmune encephalomyelitis

Autoaggressive, myelin-reactive T cells are involved in multiple sclerosis and its prototype experimental autoimmune encephalomyelitis (EAE) in mice. A peripheral negative feedback mechanism involving regulatory CD4+ and CD8+T cells (Treg) operates to suppress disease-mediating T cell responses. We...

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Hauptverfasser: Beeston, Tara, Smith, Trevor RF, Maricic, Igor, Tang, Xiaolei, Kumar, Vipin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991517/
https://ncbi.nlm.nih.gov/pubmed/20708278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.07.007
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