IFN-γ and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy

Systemic administration of IL-12 and intermittent doses of IL-2 induce complete regression of metastatic murine renal carcinoma. Here, we show that overt tumor regression induced by IL-12/pulse IL-2 is preceded by recruitment of CD8(+) T cells, vascular injury, disrupted tumor neovascularization, an...

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Detalhes bibliográficos
Main Authors: Wigginton, Jon M., Gruys, Eilene, Geiselhart, Lisa, Subleski, Jeffrey, Komschlies, Kristin L., Park, Jong-Wook, Wiltrout, Theresa A., Nagashima, Kunio, Back, Timothy C., Wiltrout, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC209333/
https://ncbi.nlm.nih.gov/pubmed/11435457
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