Age-Related Impairment of Bones' Adaptive Response to Loading in Mice Is Associated With Sex-Related Deficiencies in Osteoblasts but No Change in Osteocytes†

Bones adjust their mass and architecture to be sufficiently robust to withstand functional loading by adapting to their strain environment. This mechanism appears less effective with age, resulting in low bone mass. In male and female young adult (17-week-old) and old (19-month-old) mice, we investi...

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Veröffentlicht in:J Bone Miner Res
Hauptverfasser: Meakin, Lee B, Galea, Gabriel L, Sugiyama, Toshihiro, Lanyon, Lance E, Price, Joanna S
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2014
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258100/
https://ncbi.nlm.nih.gov/pubmed/24644060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2222
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