Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria, which induces mitophagy generating polyUb...

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Bibliografski detalji
Izdano u:PLoS Genet
Glavni autori: Shiba-Fukushima, Kahori, Arano, Taku, Matsumoto, Gen, Inoshita, Tsuyoshi, Yoshida, Shigeharu, Ishihama, Yasushi, Ryu, Kwon-Yul, Nukina, Nobuyuki, Hattori, Nobutaka, Imai, Yuzuru
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256268/
https://ncbi.nlm.nih.gov/pubmed/25474007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004861
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