Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria, which induces mitophagy generating polyUb...

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Vydáno v:PLoS Genet
Hlavní autoři: Shiba-Fukushima, Kahori, Arano, Taku, Matsumoto, Gen, Inoshita, Tsuyoshi, Yoshida, Shigeharu, Ishihama, Yasushi, Ryu, Kwon-Yul, Nukina, Nobuyuki, Hattori, Nobutaka, Imai, Yuzuru
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256268/
https://ncbi.nlm.nih.gov/pubmed/25474007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004861
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