Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual SOS...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Iversen, Lars, Tu, Hsiung-Lin, Lin, Wan-Chen, Christensen, Sune M., Abel, Steven M., Iwig, Jeff, Wu, Hung-Jen, Gureasko, Jodi, Rhodes, Christopher, Petit, Rebecca S., Hansen, Scott D., Thill, Peter, Yu, Cheng-Han, Stamou, Dimitrios, Chakraborty, Arup K., Kuriyan, John, Groves, Jay T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255705/
https://ncbi.nlm.nih.gov/pubmed/24994643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250373
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