H-Ras forms dimers on membrane surfaces via a protein–protein interface

The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A number of observations suggest that Ras is laterally organized within the cell membrane, and this may play a regulatory role in its activation. Lipid anchors composed of palmitoyl and farnesyl moieties in H-, N-...

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Bibliographic Details
Main Authors: Lin, Wan-Chen, Iversen, Lars, Tu, Hsiung-Lin, Rhodes, Christopher, Christensen, Sune M., Iwig, Jeffrey S., Hansen, Scott D., Huang, William Y. C., Groves, Jay T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939930/
https://ncbi.nlm.nih.gov/pubmed/24516166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321155111
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