Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual SOS...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Science
Hlavní autoři: Iversen, Lars, Tu, Hsiung-Lin, Lin, Wan-Chen, Christensen, Sune M., Abel, Steven M., Iwig, Jeff, Wu, Hung-Jen, Gureasko, Jodi, Rhodes, Christopher, Petit, Rebecca S., Hansen, Scott D., Thill, Peter, Yu, Cheng-Han, Stamou, Dimitrios, Chakraborty, Arup K., Kuriyan, John, Groves, Jay T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255705/
https://ncbi.nlm.nih.gov/pubmed/24994643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250373
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky