Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

Activation of the small guanosine triphosphatase H-Ras by the exchange factor Son of Sevenless (SOS) is an important hub for signal transduction. Multiple layers of regulation, through protein and membrane interactions, govern activity of SOS. We characterized the specific activity of individual SOS...

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Publicat a:Science
Autors principals: Iversen, Lars, Tu, Hsiung-Lin, Lin, Wan-Chen, Christensen, Sune M., Abel, Steven M., Iwig, Jeff, Wu, Hung-Jen, Gureasko, Jodi, Rhodes, Christopher, Petit, Rebecca S., Hansen, Scott D., Thill, Peter, Yu, Cheng-Han, Stamou, Dimitrios, Chakraborty, Arup K., Kuriyan, John, Groves, Jay T.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255705/
https://ncbi.nlm.nih.gov/pubmed/24994643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1250373
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