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Membrane-dependent Signal Integration by the Ras Activator Son of Sevenless
The kinetics of Ras activation by Son of Sevenless (SOS) changes profoundly when Ras is tethered to membranes, instead of being in solution. SOS has two binding sites for Ras, one of which is an allosteric site that is distal to the active site. The activity of the SOS catalytic unit (SOS(cat)) is u...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440660/ https://ncbi.nlm.nih.gov/pubmed/18454158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1418 |
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