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Membrane-dependent Signal Integration by the Ras Activator Son of Sevenless

The kinetics of Ras activation by Son of Sevenless (SOS) changes profoundly when Ras is tethered to membranes, instead of being in solution. SOS has two binding sites for Ras, one of which is an allosteric site that is distal to the active site. The activity of the SOS catalytic unit (SOS(cat)) is u...

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Sonraí Bibleagrafaíochta
Main Authors: Gureasko, Jodi, Galush, William J., Boykevisch, Sean, Sondermann, Holger, Bar-Sagi, Dafna, Groves, Jay T., Kuriyan, John
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440660/
https://ncbi.nlm.nih.gov/pubmed/18454158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1418
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