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The Interdependent Activation of Son-of-Sevenless and Ras

The guanine-nucleotide exchange factor (GEF) Son-of-Sevenless (SOS) plays a critical role in metazoan signaling by converting Ras•GDP (guanosine diphosphate) to Ras•GTP (guanosine triphosphate) in response to tyrosine kinase activation. Structural studies have shown that SOS differs from other Ras-s...

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Bibliografiske detaljer
Udgivet i:Cold Spring Harb Perspect Med
Main Authors: Bandaru, Pradeep, Kondo, Yasushi, Kuriyan, John
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360870/
https://ncbi.nlm.nih.gov/pubmed/29610148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031534
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