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The Interdependent Activation of Son-of-Sevenless and Ras
The guanine-nucleotide exchange factor (GEF) Son-of-Sevenless (SOS) plays a critical role in metazoan signaling by converting Ras•GDP (guanosine diphosphate) to Ras•GTP (guanosine triphosphate) in response to tyrosine kinase activation. Structural studies have shown that SOS differs from other Ras-s...
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| Udgivet i: | Cold Spring Harb Perspect Med |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6360870/ https://ncbi.nlm.nih.gov/pubmed/29610148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a031534 |
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