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Differences in flexibility underlie functional differences in the Ras activators Son of sevenless and Ras Guanine Nucleotide Releasing Factor 1
The Ras-specific nucleotide exchange factor Son of sevenless (Sos) is inactive without Ras bound to a distal allosteric site. In contrast, the catalytic domain of Ras Guanine Nucleotide Releasing Factor 1 (RasGRF1) is active intrinsically. By substituting residues from RasGRF1 into Sos, we have gene...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654222/ https://ncbi.nlm.nih.gov/pubmed/19141281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.11.004 |
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