Differences in flexibility underlie functional differences in the Ras activators Son of sevenless and Ras Guanine Nucleotide Releasing Factor 1

The Ras-specific nucleotide exchange factor Son of sevenless (Sos) is inactive without Ras bound to a distal allosteric site. In contrast, the catalytic domain of Ras Guanine Nucleotide Releasing Factor 1 (RasGRF1) is active intrinsically. By substituting residues from RasGRF1 into Sos, we have gene...

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Bibliographic Details
Main Authors: Freedman, Tanya S., Sondermann, Holger, Kuchment, Olga, Friedland, Gregory D., Kortemme, Tanja, Kuriyan, John
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654222/
https://ncbi.nlm.nih.gov/pubmed/19141281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.11.004
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