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Computational docking and solution x-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless

The Ras-specific nucleotide exchange factor son of sevenless (SOS) is a large, multidomain protein with complex regulation, including a Ras-dependent allosteric mechanism. The N-terminal segment of SOS, the histone domain, contains two histone folds, which is highly unusual for a cytoplasmic protein...

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Detalhes bibliográficos
Main Authors: Sondermann, Holger, Nagar, Bhushan, Bar-Sagi, Dafna, Kuriyan, John
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276615/
https://ncbi.nlm.nih.gov/pubmed/16267129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508315102
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