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SGK3 mediates INPP4B-dependent PI 3-Kinase signaling in breast cancer

Oncogenic mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide 3-kinase (PI 3-K), occur with high frequency in breast cancer. The protein kinase Akt is considered to be the primary effector of PIK3CA, although mechanisms by which PI 3-K mediates Akt-independent tumorigeni...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Gasser, Jessica A., Inuzuka, Hiroyuki, Lau, Alan W., Wei, Wenyi, Beroukhim, Rameen, Toker, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255362/
https://ncbi.nlm.nih.gov/pubmed/25458846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.023
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