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Activation of PI3-Kinase Stimulates Endocytosis of ROMK via Akt1/SGK1-Dependent Phosphorylation of WNK1

WNK kinases stimulate endocytosis of ROMK channels to regulate renal K+ handling. Phosphatidylinositol 3-kinase (PI3K)-activating hormones, such as insulin and IGF 1, phosphorylate WNK1, but how this affects the regulation of ROMK abundance is unknown. Here, serum starvation of ROMK-transfected HEK...

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Hlavní autoři: Cheng, Chih-Jen, Huang, Chou-Long
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060440/
https://ncbi.nlm.nih.gov/pubmed/21355052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010060681
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