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Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms

WNK kinases are serine-threonine kinases with an atypical placement of the catalytic lysine. Intronic deletions with increased expression of a ubiquitous long WNK1 transcript cause pseudohypoaldosteronism type 2 (PHA II), characterized by hypertension and hyperkalemia. Here, we report that long WNK1...

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Detalhes bibliográficos
Main Authors: Lazrak, Ahmed, Liu, Zhen, Huang, Chou-Long
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360592/
https://ncbi.nlm.nih.gov/pubmed/16428287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510609103
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