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Domains of WNK1 kinase in the regulation of ROMK1
WNK1 kinase belongs to a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine. Increased expression of WNK1 causes hypertension and hyperkalemia in humans. WNK1 inhibits renal potassium channel ROMK1 by enhancing its endocytosis, likely contributing to hyperk...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519181/ https://ncbi.nlm.nih.gov/pubmed/18550644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90287.2008 |
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