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Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels

WNK4 (with no lysine kinase 4) inhibits ROMK channel activity in the distal nephron by stimulating clathrin-dependent endocytosis, an effect attenuated by SGK1 (serum-glucocorticoids-induced kinase)-mediated phosphorylation. It has been suggested that increased ROMK activity because of SGK1-mediated...

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Detalhes bibliográficos
Main Authors: Yue, Peng, Lin, Dao-Hong, Pan, Chun-Yang, Leng, Qiang, Giebisch, Gerhard, Lifton, Richard P., Wang, Wen-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736404/
https://ncbi.nlm.nih.gov/pubmed/19706464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907855106
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