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Intrinsic Islet Heterogeneity and Gap Junction Coupling Determine Spatiotemporal Ca(2+) Wave Dynamics
Insulin is released from the islets of Langerhans in discrete pulses that are linked to synchronized oscillations of intracellular free calcium ([Ca(2+)](i)). Associated with each synchronized oscillation is a propagating calcium wave mediated by Connexin36 (Cx36) gap junctions. A computational isle...
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| Vydáno v: | Biophys J |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Biophysical Society
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255172/ https://ncbi.nlm.nih.gov/pubmed/25468351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.048 |
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