How Heterogeneity in Glucokinase and Gap-Junction Coupling Determines the Islet [Ca(2+)] Response

Understanding how cell subpopulations in a tissue impact overall system function is challenging. There is extensive heterogeneity among insulin-secreting β-cells within islets of Langerhans, including their insulin secretory response and gene expression profile, and this heterogeneity can be altered...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Dwulet, JaeAnn M., Ludin, Nurin W.F., Piscopio, Robert A., Schleicher, Wolfgang E., Moua, Ong, Westacott, Matthew J., Benninger, Richard K.P.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2019
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895742/
https://ncbi.nlm.nih.gov/pubmed/31753287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.10.037
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