Intrinsic Islet Heterogeneity and Gap Junction Coupling Determine Spatiotemporal Ca(2+) Wave Dynamics

Insulin is released from the islets of Langerhans in discrete pulses that are linked to synchronized oscillations of intracellular free calcium ([Ca(2+)](i)). Associated with each synchronized oscillation is a propagating calcium wave mediated by Connexin36 (Cx36) gap junctions. A computational isle...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Benninger, Richard K.P., Hutchens, Troy, Head, W. Steven, McCaughey, Michael J., Zhang, Min, Le Marchand, Sylvain J., Satin, Leslie S., Piston, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Systems Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255172/
https://ncbi.nlm.nih.gov/pubmed/25468351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.10.048
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