Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

Insulin is secreted from the islets of Langerhans in coordinated pulses. These pulses are thought to lead to plasma insulin oscillations, which are putatively more effective in lowering blood glucose than continuous levels of insulin. Gap-junction coupling of β-cells by connexin-36 coordinates intra...

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Главные авторы: Head, W. Steven, Orseth, Meredith L., Nunemaker, Craig S., Satin, Leslie S., Piston, David W., Benninger, Richard K.P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2012
Предметы:
Islet Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379660/
https://ncbi.nlm.nih.gov/pubmed/22511206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1312
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