Connexin-36 Gap Junctions Regulate In Vivo First- and Second-Phase Insulin Secretion Dynamics and Glucose Tolerance in the Conscious Mouse

Insulin is secreted from the islets of Langerhans in coordinated pulses. These pulses are thought to lead to plasma insulin oscillations, which are putatively more effective in lowering blood glucose than continuous levels of insulin. Gap-junction coupling of β-cells by connexin-36 coordinates intra...

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Bibliografske podrobnosti
Main Authors: Head, W. Steven, Orseth, Meredith L., Nunemaker, Craig S., Satin, Leslie S., Piston, David W., Benninger, Richard K.P.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2012
Teme:
Islet Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379660/
https://ncbi.nlm.nih.gov/pubmed/22511206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1312
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