Decreasing Cx36 Gap Junction Coupling Compensates for Overactive K(ATP) Channels to Restore Insulin Secretion and Prevent Hyperglycemia in a Mouse Model of Neonatal Diabetes

Mutations to the ATP-sensitive K(+) channel (K(ATP) channel) that reduce the sensitivity of ATP inhibition cause neonatal diabetes mellitus via suppression of β-cell glucose-stimulated free calcium activity ([Ca(2+)](i)) and insulin secretion. Connexin-36 (Cx36) gap junctions also regulate islet ele...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Nguyen, Linda M., Pozzoli, Marina, Hraha, Thomas H., Benninger, Richard K.P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Diabetes Association 2014
Konular:
Islet Studies
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994954/
https://ncbi.nlm.nih.gov/pubmed/24458355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1048
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller