Decreasing Cx36 Gap Junction Coupling Compensates for Overactive K(ATP) Channels to Restore Insulin Secretion and Prevent Hyperglycemia in a Mouse Model of Neonatal Diabetes

Mutations to the ATP-sensitive K(+) channel (K(ATP) channel) that reduce the sensitivity of ATP inhibition cause neonatal diabetes mellitus via suppression of β-cell glucose-stimulated free calcium activity ([Ca(2+)](i)) and insulin secretion. Connexin-36 (Cx36) gap junctions also regulate islet ele...

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Autores principales: Nguyen, Linda M., Pozzoli, Marina, Hraha, Thomas H., Benninger, Richard K.P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2014
Materias:
Islet Studies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994954/
https://ncbi.nlm.nih.gov/pubmed/24458355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1048
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