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Decreases in Gap Junction Coupling Recovers Ca(2+) and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise
Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile secretory response at elevated glucose and suppressing...
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| Gepubliceerd in: | PLoS Comput Biol |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5040430/ https://ncbi.nlm.nih.gov/pubmed/27681078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005116 |
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