Structural and Mechanistic Insights into the Recruitment of Talin by RIAM in Integrin Signaling

Plasma membrane (PM)-bound GTPase Rap1 recruits the Rap1-interacting-adaptor-molecule (RIAM), which in turn recruits talin to bind and activate integrins. However, it is unclear how RIAM recruits talin and why its close homolog lamellipodin does not. Here we report that, although RIAM possesses two...

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Détails bibliographiques
Publié dans:Structure
Auteurs principaux: Chang, Yu-Chung, Zhang, Hao, Franco-Barraza, Janusz, Brennan, Mark L., Patel, Tejash, Cukierman, Edna, Wu, Jinhua
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255149/
https://ncbi.nlm.nih.gov/pubmed/25465129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.09.020
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