Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation

RAP1-interacting adapter molecule (RIAM) mediates RAP1-induced integrin activation. The RAS-association (RA) segment of the RA-PH module of RIAM interacts with GTP-bound RAP1 and phosphoinositol 4,5 bisphosphate but this interaction is inhibited by the N-terminal segment of RIAM. Here we report the...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Chang, Yu-Chung, Su, Wenjuan, Cho, Eun-ah, Zhang, Hao, Huang, Qingqiu, Philips, Mark R., Wu, Jinhua
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397589/
https://ncbi.nlm.nih.gov/pubmed/30733287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818880116
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