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The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism
The small GTPase Rap1 induces integrin activation via an inside-out signaling pathway mediated by the Rap1-interacting adaptor molecule (RIAM). Blocking this pathway may suppress tumor metastasis and other diseases that are related to hyperactive integrins. However, the molecular basis for the speci...
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| Publicado no: | J Mol Cell Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4817127/ https://ncbi.nlm.nih.gov/pubmed/24287201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjt044 |
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