Rap1 and its effector RIAM are required for lymphocyte trafficking

Regulation of integrins is critical for lymphocyte adhesion to endothelium and trafficking through secondary lymphoid organs. Inside-out signaling to integrins is mediated by the small GTPase Rap1. Two effectors of Rap1 regulate integrins, RapL and Rap1 interacting adaptor molecule (RIAM). Using mic...

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Bibliographic Details
Published in:Blood
Main Authors: Su, Wenjuan, Wynne, Joseph, Pinheiro, Elaine M., Strazza, Marianne, Mor, Adam, Montenont, Emilie, Berger, Jeffrey, Paul, David S., Bergmeier, Wolfgang, Gertler, Frank B., Philips, Mark R.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683330/
https://ncbi.nlm.nih.gov/pubmed/26324702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-644104
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