Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice

Talin is an integrin adaptor, which controls integrin activity in all hematopoietic cells. How intracellular signals promote talin binding to the integrin tail leading to integrin activation is still poorly understood, especially in leukocytes. In vitro studies identified an integrin activation comp...

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Bibliographic Details
Published in:Blood
Main Authors: Klapproth, Sarah, Sperandio, Markus, Pinheiro, Elaine M., Prünster, Monika, Soehnlein, Oliver, Gertler, Frank B., Fässler, Reinhard, Moser, Markus
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2015
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683331/
https://ncbi.nlm.nih.gov/pubmed/26337492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-647453
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