Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice

Talin is an integrin adaptor, which controls integrin activity in all hematopoietic cells. How intracellular signals promote talin binding to the integrin tail leading to integrin activation is still poorly understood, especially in leukocytes. In vitro studies identified an integrin activation comp...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Klapproth, Sarah, Sperandio, Markus, Pinheiro, Elaine M., Prünster, Monika, Soehnlein, Oliver, Gertler, Frank B., Fässler, Reinhard, Moser, Markus
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2015
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683331/
https://ncbi.nlm.nih.gov/pubmed/26337492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-647453
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires