Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice

Talin is an integrin adaptor, which controls integrin activity in all hematopoietic cells. How intracellular signals promote talin binding to the integrin tail leading to integrin activation is still poorly understood, especially in leukocytes. In vitro studies identified an integrin activation comp...

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Publicat a:Blood
Autors principals: Klapproth, Sarah, Sperandio, Markus, Pinheiro, Elaine M., Prünster, Monika, Soehnlein, Oliver, Gertler, Frank B., Fässler, Reinhard, Moser, Markus
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2015
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683331/
https://ncbi.nlm.nih.gov/pubmed/26337492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-647453
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