Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector

Adaptive immunity depends on lymphocyte adhesion that is mediated by the integrin lymphocyte functional antigen 1 (LFA-1). The small guanosine triphosphatase Rap1 regulates LFA-1 adhesiveness through one of its effectors, Rap1-interacting adapter molecule (RIAM). We show that RIAM was recruited to t...

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Bibliografiske detaljer
Main Authors: Wynne, Joseph P., Wu, Jinhua, Su, Wenjuan, Mor, Adam, Patsoukis, Nikolaos, Boussiotis, Vassiliki A., Hubbard, Stevan R., Philips, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2012
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471229/
https://ncbi.nlm.nih.gov/pubmed/23045549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201201157
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