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Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion
The membrane localization and activation of cytoskeletal protein talin are key steps to initiate integrin transmembrane receptors activation, which mediates many cellular adhesive responses such as cell migration, spreading, and proliferation. RIAM, a membrane anchor and small GTPase RAP1 effector,...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4432866/ https://ncbi.nlm.nih.gov/pubmed/25520155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6880 |
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