A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

The activation of heterodimeric (α/β) integrin transmembrane receptors by cytosolic protein talin is crucial for regulating diverse cell-adhesion-dependent processes, including blood coagulation, tissue remodeling, and cancer metastasis. This process is triggered by the coincident binding of N-termi...

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Detalhes bibliográficos
Main Authors: Song, Xianqiang, Yang, Jun, Hirbawi, Jamila, Ye, Sheng, Perera, H Dhanuja, Goksoy, Esen, Dwivedi, Pallavi, Plow, Edward F, Zhang, Rongguang, Qin, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494399/
https://ncbi.nlm.nih.gov/pubmed/22710802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.97
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