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Membrane targeting of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation
Kindlin-2 belongs to an emerging class of regulators for heterodimeric (α/β) integrin adhesion receptors. By binding to integrin β cytoplasmic tail via its C-terminal FERM-like domain, kindlin-2 promotes integrin activation. Intriguingly, this activation process depends on the N-terminus of kindlin-...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217186/ https://ncbi.nlm.nih.gov/pubmed/22078565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.08.012 |
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