Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation

Kindlins are a subclass of FERM-containing proteins that have recently emerged as key regulators of integrin receptor activation and signaling. As compared with the conventional FERM domain, the kindlin FERM domain contains an inserted pleckstrin homology (PH) domain that recognizes membrane phospho...

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Autors principals: Liu, Jianmin, Fukuda, Koichi, Xu, Zhen, Ma, Yan-Qing, Hirbawi, Jamila, Mao, Xian, Wu, Chuanyue, Plow, Edward F., Qin, Jun
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234820/
https://ncbi.nlm.nih.gov/pubmed/22030399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.295352
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