Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation

Kindlins are a subclass of FERM-containing proteins that have recently emerged as key regulators of integrin receptor activation and signaling. As compared with the conventional FERM domain, the kindlin FERM domain contains an inserted pleckstrin homology (PH) domain that recognizes membrane phospho...

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Detalhes bibliográficos
Main Authors: Liu, Jianmin, Fukuda, Koichi, Xu, Zhen, Ma, Yan-Qing, Hirbawi, Jamila, Mao, Xian, Wu, Chuanyue, Plow, Edward F., Qin, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234820/
https://ncbi.nlm.nih.gov/pubmed/22030399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.295352
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