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Structural and Mechanistic Insights into the Recruitment of Talin by RIAM in Integrin Signaling
Plasma membrane (PM)-bound GTPase Rap1 recruits the Rap1-interacting-adaptor-molecule (RIAM), which in turn recruits talin to bind and activate integrins. However, it is unclear how RIAM recruits talin and why its close homolog lamellipodin does not. Here we report that, although RIAM possesses two...
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| Publicat a: | Structure |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255149/ https://ncbi.nlm.nih.gov/pubmed/25465129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.09.020 |
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