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TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

Ectodomain shedding mediated by tumor necrosis factor–α (TNF-α)–converting enzyme [TACE; also known as ADAM17 (a disintegrin and metalloproteinase 17)] provides an important switch in regulating cell proliferation, inflammation, and cancer progression. TACE-mediated ectodomain cleavage is activated...

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Bibliografiske detaljer
Udgivet i:Sci Signal
Main Authors: Xu, Pinglong, Liu, Jianming, Sakaki-Yumoto, Masayo, Derynck, Rik
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254802/
https://ncbi.nlm.nih.gov/pubmed/22550340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002689
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