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Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation
Inflammatory stimuli activate ectodomain shedding of TNF-α, L-selectin and other transmembrane proteins. We show that p38 MAP kinase, which is activated in response to inflammatory or stress signals, directly activates TACE, a membrane-associated metalloprotease that effects shedding in response to...
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| Publicado no: | Mol Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4240279/ https://ncbi.nlm.nih.gov/pubmed/20188673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.01.034 |
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