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TACE-mediated ectodomain shedding of the type I TGF-β receptor downregulates TGF-β signaling
Regulating TGF-β receptor presentation provides an avenue to alter a cell’s responsiveness to TGF-β. We report that activation of the Erk MAP kinase pathway decreases the TGF-β-induced Smad3 activation, due to decreased cell surface levels of the type I receptor TβRI, but not the type II receptor. I...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740991/ https://ncbi.nlm.nih.gov/pubmed/19595713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.018 |
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