TACE-mediated ectodomain shedding of the type I TGF-β receptor downregulates TGF-β signaling

Regulating TGF-β receptor presentation provides an avenue to alter a cell’s responsiveness to TGF-β. We report that activation of the Erk MAP kinase pathway decreases the TGF-β-induced Smad3 activation, due to decreased cell surface levels of the type I receptor TβRI, but not the type II receptor. I...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Cheng, Xu, Pinglong, Lamouille, Samy, Xu, Jian, Derynck, Rik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740991/
https://ncbi.nlm.nih.gov/pubmed/19595713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.018
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